merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

  • merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

    产品名称：Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated
    产品型号：CBL490P
    Detect Integrin αV using this Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated validated for use in FC.

    merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPhycoerythrinMonoclonal Antibody
    描述
    产品目录编号 CBL490P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated
    Alternate Names
    • CD51
    产品信息
    格式 Phycoerythrin
    演示 The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 Detect Integrin αV using this Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated validated for use in FC.
    主要应用
    • Flow Cytometry
    应用说明 Bone resorption modulation

    Osteoclast identification

    Purification of the vitronectin receptor

    Malignant melanoma identification (and possible treatment)

    The antibody is only reactive on frozen sections

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human osteoclastoma tissue
    克隆 13C2
    宿主 Mouse
    特异性 This antibody recognizes a 110/90 kDa antigen known as the alpha-chain of the vitronectin receptor (VNR). This forms a complex with the CD61 antigen and mediates cell adhesion to RGD (arg-gly-asp) containing sequences in vitronectin, von Willebrand factor, fibrinogen and thrombospondin. This antibody reacts with osteoclasts, placenta and melanoma cell lines, some endothelial cells, smooth muscle cells and fibroblasts, and weakly with platelets.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002210.2
    Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
    基因符号
    • VNRA
    • ITGAV
    • DKFZp686A08142
    • MSK8
    • CD51
    UniProt编号
    • P06756
    UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1048 amino acids; 116038 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

上一件merck millipore产品：merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated
下一件merck millipore产品：merck millipore,默克密理博,574712,Syk Inhibitor II - CAS 227449-73-2 - Calbiochem


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merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated

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