merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2011,Anti-Mucin MUC5AC Antibody, clone CLH2

  • merck millipore,默克密理博,MAB2011,Anti-Mucin MUC5AC Antibody, clone CLH2

    产品名称：Anti-Mucin MUC5AC Antibody, clone CLH2
    产品型号：MAB2011
    Anti-Mucin MUC5AC Antibody, clone CLH2 detects level of Mucin MUC5AC & has been published & validated for use in ELISA, IP, WB, IC, IH(P).

    merck millipore,默克密理博,MAB2011,Anti-Mucin MUC5AC Antibody, clone CLH2

  • 产品介绍
  • merck millipore,默克密理博,MAB2011,Anti-Mucin MUC5AC Antibody, clone CLH2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, ELISA, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2011
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Mucin MUC5AC Antibody, clone CLH2
    Alternate Names
    • Gastric Mucin
    背景信息 Mucins are high molecular weight glycoproteins that are heavily glycosylated with oligosaccharide side chains linked O-glycosidically to the protein backbone. At least nine mucin genes have been identified to date. The pattern of tissue and cell-specific expression of these mucin genes suggests a distinct role for each member of the diverse mucin family. In epithelial cancers, many of the phenotypic markers for pre-malignant and malignant cells have been found on the carbohydrate and peptide moieties of mucin glycoproteins. Deregulation of tissue and cell-specific expression of mucin genes has also been described in epithelial cancers. At present, the role of mucin glyoproteins in various states of epithelial cell carcinogenesis, including the pre-neoplastic state and metastasis, is under investigation.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid at 1 mg/mL in 0.02M phosphate buffer, 0.25 M sodium chloride, 0.1% sodium azide, pH 7.6.
    应用
    应用 Anti-Mucin MUC5AC Antibody, clone CLH2 detects level of Mucin MUC5AC & has been published & validated for use in ELISA, IP, WB, IC, IH(P).
    主要应用
    • Immunocytochemistry
    • ELISA
    • Western Blotting
    应用说明 Western blot:Clone CLH2 shows a weak reactivity with a high molecular weight smear characteristic of mucin from a native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma. Typical dilution is 1:100.

    Immunocytochemistry

    Immunohistochemistry. Effective on frozen and paraffin sections at 1:1000-1:2000 dilution.

    ELISA

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Directed against a synthetic peptide of the MUC5AC tandem repeat.
    克隆 CLH2
    宿主 Mouse
    特异性 Antibody MAB2011 is specific for the MUC5AC tandem repeat of human mucin. No cross reactivity with other peptides from MUC2, 3, 6, or 7.

    Immunoreactivity of MAB2011 has been detected in the following normal human epithelial tissues: bronchus, endocervix, stomach, and gallbladder. The predominant staining pattern in normal tissues is perinuclear. Antibody reactivity has been observed in foveolar and mucopeptic neck cells of normal gastric mucosa. The expression of MUC5AC has been frequently observed in gastric carcinomas and may be used as a marker of gastric differentiation.

    The CLH2 antibody shows a weak reactivity with a high molecular weight smear characteristic of mucin from native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma .

    The antibody was generated by immunizing mice with a synthetic tandem repeat peptide The antibody recognizes the sequence TTSTTSAP within the tandem repeat of MUC5AC (1). It further recognizes glycosylated as well as unglycosylated MUC5AC.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005961.2
    基因符号
    • MUC6
    UniProt编号
    • Q6W4X9
    UniProt汇总 FUNCTION: SwissProt: Q6W4X9 # May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
    SIZE: 2392 amino acids; 252165 Da
    SUBUNIT: Multimer; disulfide-linked.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
    DEVELOPMENTAL STAGE: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.
    PTM: O-glycosylated.
    SIMILARITY: SwissProt: Q6W4X9 ## Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 1 TIL (trypsin inhibitory-like) domain. & Contains 3 VWFD domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2011,Anti-Mucin MUC5AC Antibody, clone CLH2

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