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%5BABS552_IHC(P)-ALL%5D.jpg "merck millipore,默克密理博,ABS552,Anti-p40 Antibody")
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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS552 描述 Anti-p40 Antibody Alternate Names - p51
- Tumor protein 63
- p63
- Chronic ulcerative stomatitis protein
- CUSP
- Keratinocyte transcription factor KET
- Transformation-related protein 63
- TP63
- Tumor protein p73-like
- p73L
- p40
背景信息 p40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a member of the p53 protein family. p40 is a sequence specific DNA binding transcriptional activator or repressor depending upon the target gene and the isoform involved. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specificactivity. p40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover p40, developmentally, is required for proper limb formation. p40 is expressed widely, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Mutations in p40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome), Ankyloblepharon-ectodermal defects cleft lip/palate disorder (AEC), Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), Split-hand/foot malformation 4 (SHFM4), Limb-mammary syndrome (LMS), Ectodermal dysplasia, Rapp-Hodgkin type (EDRH), Non-syndromic orofacial cleft 8 (OFC8). 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-p40 | ABS552 is an antibody against p40 for use in Western Blotting, Immunohistochemistry (Paraffin). 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: 2.0 µg/mL from a representative lot detected p40 in 10 µg of human liver and human skin tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Isocitrate dehydrogenase in squamous carcinoma cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the transcription activation domain of human p40. 表位 Transcription activation domain 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 特异性 Uniprot describes multiple isoforms for this protein and based on the immunogen this antibody should recognize isoforms 2,4,6,8,10 and 12. 品种反应性 Human Species Reactivity Note Human. Predicted to react with Mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001108454
基因符号 - TP73L
- TP63
- KET
- P63
- P73H
- P73L
纯化方法 Affinity purified UniProt编号 - Q9H3D4
产品使用声明 质量保证 Evaluated by Western Blotting in human heart tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected p40 in 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,203724,BRIJ 35 Detergent, 30% Aqueous Solution - CAS 9002-92-0 - Calbiochem
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