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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, IHC Rb Purified Polyclonal Antibody 描述 产品目录编号 06-676 品牌系列 Upstate
商名 - Upstate
描述 Anti-mGluR2/3 Antibody 产品信息 格式 Purified 演示 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol 应用 应用 Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2 宿主 Rabbit 特异性 mGluR2 and mGluR3 同种型 IgG 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000839 / NM_000840
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. 基因符号 - mGluR2
- GRM2
- GPRC1B
- MGLUR2
- GLUR2
- mGlu2
纯化方法 Protein A chromatography UniProt编号 - Q14416
UniProt汇总 FUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
SIZE: 872 amino acids; 95568 Da
SUBUNIT: Interacts with GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.产品使用声明 质量保证 routinely evaluated by immunoblot on rat brain microsomal preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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