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merck millipore,默克密理博,574712,Syk Inhibitor II - CAS 227449-73-2 - Calbiochem
产品名称：Syk Inhibitor II - CAS 227449-73-2 - Calbiochem
产品型号：574712
The Syk Inhibitor II, also referenced under CAS 227449-73-2, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicatio More>>
merck millipore,默克密理博,574712,Syk Inhibitor II - CAS 227449-73-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₁₅F₃N₆O • 2HCl•2H₂O 227449-73-2 描述 概述 A cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCε, PKCβII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Inhibits FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.). 产品目录编号 574712 品牌系列 Calbiochem®
同义词 2-(2-Aminoethylamino)-4-(3-trifluoromethylanilino)-pyrimidine-5-carboxamide, Dihydrochloride, Dihydrate 参考 参考 Hisamichi, H., et al. 2005. Bioorg. Med. Chem. 13, 4936. 产品信息 CAS号 227449-73-2 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₄H₁₅F₃N₆O • 2HCl•2H₂O 化学配方 C₁₄H₁₅F₃N₆O • 2HCl•2H₂O Molar Mass 449.3 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 Syk 主靶IC50 41 nM against Syk; 460 nM against FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O or DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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