- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-551 品牌系列 Upstate
商名 - Upstate
描述 Anti-E2F-3 Antibody, clone PG37 背景信息 E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F 3 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides. 产品信息 格式 Purified 控制 - HeLa nuclear extract
演示 PBS, pH 7.4 应用 应用 Detect E2F-3 with Anti-E2F-3 Antibody, clone PG37 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Recombinant full-length human E2F-3 protein 克隆 clone PG37 宿主 Mouse 特异性 E2F-3 同种型 IgG2a 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001949
Entrez基因汇总 The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. 基因符号 - DKFZp686C18211
- E2F3
- KIAA0075
- E2F-3
- MGC104598
纯化方法 Protein A purfied UniProt编号 - O00716
UniProt汇总 FUNCTION: SwissProt: O00716 # Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner.
SIZE: 465 amino acids; 49162 Da
SUBUNIT: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: O00716 ## Belongs to the E2F/DP family.产品使用声明 质量保证 routinely evaluated by immunoblot on HeLa nuclear extract or mouse 3T3 nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 2-8°C 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MADPNMAG-70K-01,MILLIPLEX MAP Mouse Adiponectin Magnetic Bead- Single Plex - Endocrine Assay
下一件merck millipore产品：merck millipore,默克密理博,15-205,Amyloid Beta Precursor Proteins Explorer Antibody MiniPack
相关产品
merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated
merck millipore,默克密理博,CBL490P,Anti-Integrin αV Antibody, clone 13C2, Phycoerythrin conjugated
merck millipore,默克密理博,574712,Syk Inhibitor II - CAS 227449-73-2 - Calbiochem
merck millipore,默克密理博,197223,Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem
merck millipore,默克密理博,15-205,Amyloid Beta Precursor Proteins Explorer Antibody MiniPack
merck millipore,默克密理博,567530,Sodium Hydroxide, Pellets - CAS 1310-73-2 - Calbiochem
merck millipore,默克密理博,14-699,PAK5 Protein, active, 10 µg
merck millipore,默克密理博,376816,Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem
merck millipore,默克密理博,04-462,Anti-IL-1 β Antibody, rabbit monoclonal