merck millipore,默克密理博,04-462,Anti-IL-1 β Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-462,Anti-IL-1 β Antibody, rabbit monoclonal
产品名称：Anti-IL-1 β Antibody, rabbit monoclonal
产品型号：04-462
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-1 β Antibody, rabbit is validated for u More>>

merck millipore,默克密理博,04-462,Anti-IL-1 β Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-462,Anti-IL-1 β Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-462
品牌系列	Upstate
商名	Upstate
描述	Anti-IL-1 β Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-1 β Antibody, rabbit is validated for use in WB for the detection of IL-1 β.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated recombinant human IL-1 beta.
宿主	Rabbit
特异性	Recognizes recombinant human IL-1 beta.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000576.2
Entrez基因汇总	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
基因符号	Catabolin IL1B IL1F2 IL-1 IL-1B catabolin pro-interleukin-1-beta IL1-BETA
UniProt编号	P01584
UniProt汇总	FUNCTION: SwissProt: P01584 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. SIZE: 269 amino acids; 30748 Da SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. DOMAIN: SwissProt: P01584 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. SIMILARITY: Belongs to the IL-1 family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.