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品种反应性 主要应用 宿主 格式 抗体类型 M, H, Ch WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1144 Replaces MAB3264 描述 Anti-Talin Antibody, CT, clone TD77 Alternate Names - talin 1
背景信息 Talin consisting of a 47-kDa N-terminal head domain (residues 1-433) and a 190-kDa
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.产品信息 格式 Purified 控制 - Jurkat cell lysate.
演示 Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PBS pH 7.6, 0.25 M NaCl containing 0.1% sodium azide. 应用 应用 Detect Talin using this Anti-Talin Antibody, C-terminus, clone TD77 validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Talin in human GI track tissue. 生物信息 免疫原品种 Human platelet protein 表位 C-terminus 克隆 TD77 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes Human Talin, and cross reacts with Mouse and chicken Talin. The epitope recognized by this antibody is located within the C-terminal region of the protein (residues 2269-2541), which also contains an F-actin binding site homologous to that in the yeast actin-binding protein SIa2p. 同种型 IgG1 品种反应性 MouseHumanChicken Species Reactivity Note Proven to react with human. Expected cross-reactivity in mouse and chicken. 抗体类型 Monoclonal Antibody Entrez基因编号 - Q9Y490
基因符号 - TLN
- ILWEQ
- KIAA1027
纯化方法 Purified from Protein A Sepharose™ chromatography UniProt编号 - Q9Y490
UniProt汇总 FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts By similarity.
SUBUNIT STRUCTURE: Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.
SUBCELLULAR LOCATION: Cell projection › ruffle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton By similarity. Note: Colocalizes with LAYN at the membrane ruffles By similarity.
SEQUENCE SIMILARITIES: Contains 1 FERM domain.
Contains 1 I/LWEQ domain.产品使用声明 质量保证 Evaluated by Western Blot in Jurkat cell lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain between 2 and 8°C for 1 year after date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,17-651,ChIPAb+ Monomethyl-Histone H4 (Lys20) - ChIP Validated Antibody and Primer Set
下一件merck millipore产品：merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1
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