merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1

  • merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1

    产品名称：Anti-GSK-3 alpha/beta Antibody, clone 12B11.1
    产品型号：MABS77
    This Anti-GSK-3 alpha/beta Antibody, clone 12B11.1 is validated for use in Western Blotting, ICC for the detection of GSK-3 alpha/beta.

    merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1

  • 产品介绍
  • merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS77
    Replaces 04-361
    描述 Anti-GSK-3 alpha/beta Antibody, clone 12B11.1
    Alternate Names
    • Serine/threonine-protein kinase GSK3A
    • Glycogen synthase kinase-3 alpha
    • GSK-3 alpha
    背景信息 Glycogen synthase-3 alpha (GSK-3 alpha) is a ubiquitous constitutively-active multifunctional kinase. GSK-3 alpha phosphorylates serine and threonine residues on its target substrates, most of which are “primed” or prephosphorylated. It is most widely researched for its interaction with glycogen synthase which is deactivated after phosphorylation by GSK-3 alpha; this activity blocks the synthesis of glycogen and plays an important role in the regulation of glycogen. GSK-3 alpha is also involved in the Wnt/β-catenin, Notch, and Hedgehog signaling pathways and affects a wide range of cellular processes including cell-cycle regulation, transcription, and apoptosis. GSK-3 alpha also phosphorylates tau proteins and may contribute to the generation of APP-derived amyloid plaques which are involved in the pathogenesis of Alzheimer’s disease. GSK-3 alpha is also investigated for its role in type 2 diabetes, and cancer.
    产品信息
    格式 Purified
    控制
    • Jurkat cell lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 This Anti-GSK-3 alpha/beta Antibody, clone 12B11.1 is validated for use in Western Blotting, ICC for the detection of GSK-3 alpha/beta.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected GSK-3 alpha/beta in HeLa and A431 cells.
    生物信息
    免疫原品种 Ovalbumin-conjugated linear peptide corresponding to human GSK-3 alpha/beta.
    克隆 12B11.1
    宿主 Mouse
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_063937
    Entrez基因汇总 This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].
    基因符号
    • GSK-3 alpha/beta
    • GSK3A
    纯化方法 Purified by ion exchange chromatography
    UniProt编号
    • P49840
    UniProt汇总 FUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.

    CATALYTIC ACTIVITY: ATP + [tau protein] = ADP + [tau protein] phosphate.

    ATP + a protein = ADP + a phosphoprotein.

    ENZYME REGULATION: Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.

    SUBUNIT STRUCTURE: Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin.

    PTM: Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.

    MISCELLANEOUS: Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (Ref.5). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (Ref.17).

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in Jurkat cell lysate.

    Western Blot Analysis: A 1:2,000 dilution of this antibody detected GSK-3 alpha/beta on 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABS77,Anti-GSK-3 alpha/beta Antibody, clone 12B11.1

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