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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, R, M, Chp IH(P) Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS94 描述 Anti-MLK1 Antibody Alternate Names - Mixed lineage kinase 1
- Mitogen-activated protein kinase kinase kinase 9
背景信息 MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism. 产品信息 格式 Affinity Purified 控制 - Colorectal adenocarcinoma tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human MLK1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Rhesus MacaqueHumanRatMouseChimpanzee Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Rat, Mouse, Chimpanzee, and Rhesus Macaque based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_149132
基因符号 - PRKE1
- MAP3K9
- MLK1
纯化方法 Affinity purified UniProt编号 - P80192
UniProt汇总 FUNCTION: Activates the JUN N-terminal pathway.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity).
SUBUNIT STRUCTURE: Homodimer (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.
SEQUENCE CAUTION: The sequence AAI11408.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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