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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9776-50UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sloβ4 Antibody Alternate Names - KCNMB4, Ca<sup>2+</sup>-activated K<sup>+</sup> channel β subunit 4, BK<sub>Ca</sub> β subunit 4
- KCNMB4
- Ca<sup>2+</sup>-activated K<sup>+</sup> channel β subunit 4
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 This Anti-Sloβ4 Antibody is validated for use in WB for the detection of Sloβ4. 主要应用 - Western Blotting
应用说明 Western blot: 1:200 using ECL on rat brain membranes.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from amino acids 2-17 of rat sloβ4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes sloβ4 (KCNMB4, Ca2+-activated K+ channel β subunit 4, BKCa β subunit 4). 品种反应性 Rat Species Reactivity Note The immunogen sequence is identical in human and mouse. 抗体类型 Polyclonal Antibody Entrez基因汇总 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. 基因符号 - SLObeta4
- KCNMB4
- KCMB4
- BKbeta4
纯化方法 Immunoaffinity purified UniProt编号 - Q86W47
- Q9ESK8
UniProt汇总 FUNCTION: SwissProt: Q86W47 # Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
SIZE: 210 amino acids; 23949 Da
SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.DOMAIN:SwissProt: Q86W47 Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.
PTM: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. & N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
SIMILARITY: Belongs to the KCNMB family.
MISCELLANEOUS: Treatment with okadaic acid reduces its effect on KCNMA1.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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