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描述 产品目录编号 14-593 品牌系列 Upstate
商名 - Upstate
描述 HePTP Protein, 10 µg 概述 N-terminal His6-tagged, recombinant human HePTP, amino acid residues 22- end 应用 应用 N-terminal His6-tagged, recombinant human HePTP, amino acid residues 22-end, for use in Phosphatase Assays. 主要应用 - Phosphatase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme Entrez基因编号 - NM_080588.1
- NM_002832.2
Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - PTPNI
- PTPN7
- BPTP-4
- LC-PTP
- LPTP
- HEPTP
蛋白靶 HePTP 纯化方法 Ni2+/NTA-agarose 靶子系列 Tyr phosphatase UniProt编号 - P35236
UniProt汇总 FUNCTION: SwissProt: P35236 # Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
SIZE: 360 amino acids; 40529 Da
SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen.
PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
SIMILARITY: SwissProt: P35236 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. & Contains 1 tyrosine-protein phosphatase domain.产品使用声明 质量保证 routinely evaluated by dephosphorylation of 100μM DiFMUP 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C from date of shipment 包装信息 数量 10 µg 包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-593M when ordering the 250 µg size.
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