merck millipore,默克密理博,AB15320,Anti-Nicotinic Acetylcholine Receptor α3 Antibody

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merck millipore,默克密理博,AB15320,Anti-Nicotinic Acetylcholine Receptor α3 Antibody
产品名称：Anti-Nicotinic Acetylcholine Receptor α3 Antibody
产品型号：AB15320
Anti-Nicotinic Acetylcholine Receptor α3 Antibody is an antibody against Nicotinic Acetylcholine Receptor α3 for use in WB.

merck millipore,默克密理博,AB15320,Anti-Nicotinic Acetylcholine Receptor α3 Antibody

产品介绍

merck millipore,默克密理博,AB15320,Anti-Nicotinic Acetylcholine Receptor α3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, M	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB15320
描述	Anti-Nicotinic Acetylcholine Receptor α3 Antibody
Alternate Names	nicotinic cholinergic receptor alpha 1 cholinergic receptor, nicotinic, alpha 1 (muscle) cholinergic receptor, nicotinic, alpha polypeptide 1<br />(muscle) nicotinic acetylcholine receptor alpha subunit
背景信息	Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons. nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh) and is also opened by nicotine. After binding ACh, the nAChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. nAChRs are present in many tissues in the body: the neuronal receptors are present in the central nervous system and the peripheral nervous system; and the neuromuscular receptors are found in the neuromuscular junctions of somatic muscles. Neuronal AChR is composed of two different types of subunits: alpha (α) and beta (β).

产品信息
格式	Affinity Purified
控制	Rat brain lysate
演示	Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Nicotinic Acetylcholine Receptor α3 Antibody is an antibody against Nicotinic Acetylcholine Receptor α3 for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from residues within the Nicotinic Acetylcholine Receptor α3.
表位	Extracellular Domain
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes Nicotinic Acetylcholine Receptor α3.
品种反应性	RatMouse
Species Reactivity Note	Demonstrated to react with mouse, and rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_434692
Entrez基因汇总	Subunit of nicotinic acetylcholine receptor that is specific to the brain and peripheral nervous system [RGD].
基因符号	SCCMS ACHRA ACHRD CHNRA CHRNA CMS2A FCCMS
修改	Acetylation
纯化方法	Antigen affinity purified
UniProt编号	P02708
UniProt汇总	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. SUBUNIT STRUCTURE: Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus. INVOLVEMENT IN DISEASE: Defects in CHRNA1 are a cause of lethal type multiple pterygium syndrome [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. The alpha subunit is the main focus for antibody binding in myasthenia gravis [MIM:254200]. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS) [MIM:608930]. FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. SEQUENCE SIMILARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]

产品使用声明
质量保证	Evaluated by Western Blot in rat brain lysate. Western Blot Analysis: : 1:10,000 dilution of this lot detected Nicotinic Acetylcholine Receptor α3 in 10 µg of rat brain lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C for up to 12 months from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,AB15320,Anti-Nicotinic Acetylcholine Receptor α3 Antibody

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