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  • merck millipore,默克密理博,ABS92,Anti-TNK1 Antibody

  • merck millipore,默克密理博,ABS92,Anti-TNK1 Antibody

    产品名称：Anti-TNK1 Antibody
    产品型号：ABS92
    Detect TNK1 using this Anti-TNK1 Antibody validated for use in WB.

    merck millipore,默克密理博,ABS92,Anti-TNK1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABS92,Anti-TNK1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABS92
    描述 Anti-TNK1 Antibody
    Alternate Names
    • CD38 negative kinase 1
    • Non-receptor tyrosine-protein kinase TNK1
    背景信息 TNK1 (thirty-eight-negative kinase 1) is a non-receptor tyrosine kinase that is widely used in fetal development signaling and more narrowly used in adult tissues and lymphohematopoietic system cells. TNK1 seems to have regulatory ability on whether TNFalpha activates NF-kappaB or apoptosis. TNK1 can also inhibit Ras function and tumor growth. Mice with a TNK1 deficiency often show unprompted tumor growth, including lymphomas and carcinomas. TNK1 downregulation has also been shown in a large number of humans with diffuse large B-cell lymphoma.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect TNK1 using this Anti-TNK1 Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human TNK1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003976
    Entrez基因汇总 TNK1 is a nonreceptor tyrosine kinase. These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.[supplied by OMIM].
    基因符号
    • TNK1
    纯化方法 Protein A
    UniProt编号
    • Q13470
    UniProt汇总 FUNCTION: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

    CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    SUBUNIT STRUCTURE: Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.

    SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein

    TISSUE SPECIFICITY: Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Ref.4 PTM: Autophosphorylated on tyrosine residues.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family.

    Contains 1 protein kinase domain.

    Contains 1 SH3 domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected TNK1 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABS92,Anti-TNK1 Antibody

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