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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB9290 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Contactin-1 Antibody 产品信息 格式 Serum 演示 Rabbit serum. Liquid. 应用 应用 This Anti-Contactin-1 Antibody is validated for use in WB for the detection of Contactin-1. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000 on rat brain lysate. Reacts with the ~135 kDa Contactin-1 protein.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from rat Contactin-1. 宿主 Rabbit 特异性 Contactin-1. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_175038.1
- NM_001843.2
Entrez基因汇总 The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. 基因符号 - F3
- CNTN1
- GP135
UniProt编号 - Q12860
UniProt汇总 FUNCTION: SwissProt: Q12860 # Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
SIZE: 1018 amino acids; 113320 Da
SUBUNIT: Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR (By similarity).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. & Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side.
SIMILARITY: SwissProt: Q12860 ## Belongs to the immunoglobulin superfamily. Contactin family. & Contains 4 fibronectin type-III domains. & Contains 6 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,AB2910,Anti-Mcl-1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,MAB1072,Anti-Erythropoietin Antibody, clone 1C8
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