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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB2910 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Mcl-1 Antibody 产品信息 格式 Serum 演示 Liquid antiserum. 应用 应用 This Anti-Mcl-1 Antibody is validated for use in IP, WB, IH(P) for the detection of Mcl-1. 主要应用 - Western Blotting
应用说明 Immunoblot 1:2,000
Immunoprecipitation. Precipitates a 37-39 kDa protein, which appears as a doublet in some cells.
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
The following tissues/cells can serve as positive controls: tonsil, tonsillar B cells, B-cell lines Reh, Daudi, and Karpas 422.
Optimal working dilutions for AB2910 must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 121-139 of human Mcl-1. 宿主 Rabbit 特异性 Recognizes Human Mcl-1. Not reactive with other members of the Bcl-2 family, as verified by immunoblot. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_182763.1
- NM_021960.3
Entrez基因汇总 The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. 基因符号 - EAT
- MCL1
- MCL1L
- mcl1/EAT
- MGC104264
- MGC1839
- TM
- MCL1S
UniProt编号 - Q07820
UniProt汇总 FUNCTION: SwissProt: Q07820 # Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.
SIZE: 350 amino acids; 37337 Da
SUBUNIT: Interacts with BAD, BOK, BIK, BFM and PMAIP (By similarity). Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro- apoptototic BCL2-related proteins.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
PTM: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. & Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. & Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
SIMILARITY: SwissProt: Q07820 ## Belongs to the Bcl-2 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles. 包装信息 数量 100 µL
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