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merck millipore,默克密理博,219670,CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
产品名称：CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
产品型号：219670
The CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,219670,CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₁₀F₃NO₃S₂ 307510-92-5 描述 概述 A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674). 产品目录编号 219670 品牌系列 Calbiochem®
同义词 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172 参考 参考 Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.产品信息 CAS号 307510-92-5 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₈H₁₀F₃NO₃S₂ 化学配方 C₁₈H₁₀F₃NO₃S₂ Molar Mass 409.4 可逆 Y 结构配方图像 生物信息 主靶 CFTR 主靶Ki ~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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