merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2014,Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

  • merck millipore,默克密理博,MAB2014,Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

    产品名称：Anti-OB-Cadherin Antibody, extracellular domain, clone 16A
    产品型号：MAB2014
    Detect OB-Cadherin using this Anti-OB-Cadherin Antibody, extracellular domain, clone 16A validated for use in WB, IC, IH.

    merck millipore,默克密理博,MAB2014,Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

  • 产品介绍
  • merck millipore,默克密理博,MAB2014,Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2014
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-OB-Cadherin Antibody, extracellular domain, clone 16A
    Alternate Names
    • Cadherin-11
    背景信息 Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed.
    产品信息
    格式 Purified
    演示 Affinity purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide.
    应用
    应用 Detect OB-Cadherin using this Anti-OB-Cadherin Antibody, extracellular domain, clone 16A validated for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot: 1:25 - 1:250
    Immunohistochemistry: Frozen tissue sections. 1:25 - 1:50 dilution using avidin-biotinylated horseradish peroxidase complex (ABC) as detection protocol.
    Immunocytochemistry: Methanol and paraformaldehyde-fixed cells
    Optimal working dilutions must be determined by the end user.I/
    生物信息
    免疫原品种 Fusion protein corresponding to extracellular domain of human OB-cadherin coupled to GST.
    表位 extracellular domain
    克隆 16A
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the extracellular domain of human cadherin-11.
    同种型 IgG1
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001797.2
    Entrez基因汇总 This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
    基因符号
    • OB-cadherin
    • CDH11
    • CDHOB
    • CAD11
    • OB
    • cadherin-11
    • OSF-4
    UniProt编号
    • P55287
    UniProt汇总 FUNCTION: SwissProt: P55287 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
    SIZE: 796 amino acids; 87965 Da
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
    SIMILARITY: SwissProt: P55287 ## Contains 5 cadherin domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at 4°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2014,Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

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