merck millipore,默克密理愽
  • merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain

  • merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain

    产品名称：Anti-MT1-MMP Antibody, hemopexin domain
    产品型号：AB6070
    This Anti-MT1-MMP Antibody, hemopexin domain is validated for use in WB, IH(P) for the detection of MT1-MMP.

    merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain

  • 产品介绍
  • merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rhesus Macaque, H, R, Eq, ChpWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB6070
    Replaces AB8104
    描述 Anti-MT1-MMP Antibody, hemopexin domain
    Alternate Names
    • MT1MMP
    • Matrix metalloproteinase-14
    • MMP-14
    • MMP-X1
    • Membrane-type matrix metalloproteinase 1
    • MT-MMP 1
    • MTMMP1
    • Membrane-type-1 matrix metalloproteinase
    • MT1-MMP
    背景信息 Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade components of extracellular matrix (ECM), including collagens, fibronectin, laminin and other glycoproteins. MMPs play an important role in wound healing, apoptosis, development, angiogenesis, cancer metastases, and tissue remodeling. Most MMPs are secreted as inactive proproteins which are cleaved and activated; however, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily has a transmembrane domain suggesting these proteins are expressed at the cell’s surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of ECM components and thought to be an important tool for cellular remodeling of the ECM. It is also involved in endothelial cell migration, and although not fully characterized, MT1-MMP activity appears to modulate endothelial invasion, and formation of capillary tubes during angiogenesis. It also appears to be a factor in monocyte recruitment during inflammation. MT1-MMP also activates MMP-2 protein, an activity involved in tumor invasion.
    产品信息
    格式 Purified
    控制
    • HT-1080 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-MT1-MMP Antibody, hemopexin domain is validated for use in WB, IH(P) for the detection of MT1-MMP.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected MT1-MMP in human and rat colon tissue.
    生物信息
    免疫原品种 Recombinant protein corresponding to the entire hemopexin-like domain of MT1-MMP.
    表位 Hemopoxin Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the hemopoxin domain of MT1-MMP.
    品种反应性 Rhesus MacaqueHumanRatHorseChimpanzee
    Species Reactivity Note Demonstrated to react with Human and Rat.
    Predicted to react with Horse, Chimpanzee and Rhesus Macaque based on 100% sequence homology. Other homologies: Pig, Bovine, and Canine (98% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004986
    Entrez基因汇总 Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq].
    基因符号
    • MMP14
    纯化方法 Protein A Purified
    UniProt编号
    • P50281
    UniProt汇总 FUNCTION: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.

    CATALYTIC ACTIVITY: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.

    COFACTOR: Binds 1 zinc ion per subunit (by similarity). Calcium (by similarity).

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (potential). Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    TISSUE SPECIFICITY: Expressed in stromal cells of colon, breast, and head and neck.

    DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    POST-TRANSLATIONAL MODIFICATION: The precursor is cleaved by a furin endopeptidase (by similarity).

    SEQUENCE SIMILARITIES: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HT-1080 cell lysate.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected MT1-MMP in 10 µg of HT-1080 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain

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