merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1767,Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

  • merck millipore,默克密理博,MAB1767,Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

    产品名称：Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2
    产品型号：MAB1767
    Detect Human MT1-MMP catalytic domain using this Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2 validated for use in WB, IC, IH.

    merck millipore,默克密理博,MAB1767,Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

  • 产品介绍
  • merck millipore,默克密理博,MAB1767,Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1767
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2
    Alternate Names
    • MMP-14
    背景信息 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP-14 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion.
    产品信息
    格式 Purified
    演示 Protein A purified immunoglobulin liquid in PBS, pH 7.2, containing 0.1% sodium azide.
    应用
    应用 Detect Human MT1-MMP catalytic domain using this Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2 validated for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Suggested dilutions:
    Western blot: 1:1000 - 1:2000
    生物信息
    免疫原品种 Recombinant protein containing the catalytic domain of human MT1-MMP.
    表位 catalytic domain
    克隆 3G4.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Clone 3G4.2 recognizes the catalytic domain of MT1-MMP, identifying the active form of the protein. MW is approximately 60 kDa.
    同种型 IgG2bκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004995.2
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
    基因符号
    • EC 3.4.24.80
    • MMP14
    • MTMMP1
    • MMP-14
    • MT1MMP
    • MT1-MMP
    • MMP-X1
    UniProt编号
    • P50281
    UniProt汇总 FUNCTION: SwissProt: P50281 # Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.
    COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
    SIZE: 582 amino acids; 65884 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.
    DOMAIN: SwissProt: P50281 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at 2-8°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1767,Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

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