merck millipore,默克密理博,MAB874-KC,Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC

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merck millipore,默克密理博,MAB874-KC,Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC
产品名称：Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC
产品型号：MAB874-KC

merck millipore,默克密理博,MAB874-KC,Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC

产品介绍

merck millipore,默克密理博,MAB874-KC,Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC

描述
产品目录编号	MAB874-KC
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Papillomavirus, 16, 18 E6 protein, clone C1P5 (1mg) KC
概述	This product is intended for use by IVD manufacturers.
Alternate Names	HPV
背景信息	Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

产品信息
格式	Purified
控制	Human cervical carcinoma extract
演示	Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.

应用
主要应用	Western Blotting Immunohistochemistry
应用说明	Immunoblotting: Reactive with a 16.5-18 kDa band in reduced westerns of overexpressing cells lines corresponding to HPV E6 protein in cells derived from human cervical carcinoma. {Banks, et al 1987} Immunohistochemistry: Shows reactivity on formalin fixed tissue. Dilute with buffer pH 7.5-8.0 to desired working volumes. For extensive dilution, protein containing or other stabilizing medium should be used. Immunopreciptiation: Immunoprecipiates 16.5 kDa band from human cervical carcinoma extracts {Banks, et al, 1987}. Final working dilutions must be determined by end user.

应用

主要应用

Western Blotting
Immunohistochemistry

应用说明

Immunoblotting: Reactive with a 16.5-18 kDa band in reduced westerns of overexpressing cells lines corresponding to HPV E6 protein in cells derived from human cervical carcinoma. {Banks, et al 1987}

Immunohistochemistry: Shows reactivity on formalin fixed tissue. Dilute with buffer pH 7.5-8.0 to desired working volumes. For extensive dilution, protein containing or other stabilizing medium should be used.

Immunopreciptiation: Immunoprecipiates 16.5 kDa band from human cervical carcinoma extracts {Banks, et al, 1987}.

Final working dilutions must be determined by end user.

生物信息
免疫原品种	C1P5 was made against HPV type 18 E6 protein produced in bacteria.
表位	16, 18 E6 protein
克隆	C1P5
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Recognizes Human papilloma virus type 18 early E6 protein. The antibody cross reacts with E6 protein from HPV type 16.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
纯化方法	Protein A purfied

产品使用声明
使用声明	Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

使用声明

Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.