merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF81,Anti-ROR gamma T Antibody, clone 6F3.1

  • merck millipore,默克密理博,MABF81,Anti-ROR gamma T Antibody, clone 6F3.1

    产品名称：Anti-ROR gamma T Antibody, clone 6F3.1
    产品型号：MABF81
    This Anti-ROR gamma T Antibody, clone 6F3.1 is validated for use in WB, IH for the detection of ROR gamma T.

    merck millipore,默克密理博,MABF81,Anti-ROR gamma T Antibody, clone 6F3.1

  • 产品介绍
  • merck millipore,默克密理博,MABF81,Anti-ROR gamma T Antibody, clone 6F3.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF81
    描述 Anti-ROR gamma T Antibody, clone 6F3.1
    Alternate Names
    • Retinoid-related orphan receptor-gamma
    • Nuclear receptor ROR-gamma
    • Nuclear receptor RZR-gamma
    • Nuclear receptor subfamily 1 group F member 3
    背景信息 Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
    产品信息
    格式 Purified
    控制
    • T47D cell lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-ROR gamma T Antibody, clone 6F3.1 is validated for use in WB, IH for the detection of ROR gamma T.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected ROR gamma T in normal human liver tissues.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human ROR gamma T.
    克隆 6F3.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001001523
    Entrez基因汇总 The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • RZRG
    • RORC
    • NR1F3
    • RORG
    纯化方法 Protein G purified
    UniProt编号
    • P51449
    UniProt汇总 FUNCTION: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4+ T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Isoform 1: widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2: Primarily expressed in immature thymocytes.
    产品使用声明
    质量保证 Evaluted in Western Blot in T47D cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected ROR gamma T in 10 µg of T47D cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF81,Anti-ROR gamma T Antibody, clone 6F3.1

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