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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, ELISA, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3094 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Orexin-2 Receptor Antibody Alternate Names - Hypocretin Receptor 2
- OX2R
产品信息 格式 Affinity Purified 演示 Affinity Purified 1mg/mL solution in PBS, pH 7.4 and 0.1% BSA 应用 应用 Detect Orexin-2 Receptor using this Anti-Orexin-2 Receptor Antibody validated for use in ELISA, IH & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Western blot: 1-10 μg/mL using Chemiluminescence technique
ELISA: 1:10,000 - 100,000 against the control peptide (Catalog Number AG794).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A 19 aa peptide near the C-terminus (cytoplasmic domain) of rat OX2R. The immunogen peptide (Catalog Number AG794) is available to perform preabsorbtion controls. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Rat/Human Orexin-2. Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001517
Entrez基因汇总 HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour. 基因符号 - OX2R
- HCRTR2
- OTTHUMP00000039969
- Ox2r
UniProt编号 - O43614
UniProt汇总 FUNCTION: SwissProt: O43614 # Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
SIZE: 444 amino acids; 50680 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: O43614 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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