merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL418F,Anti-Endoglin Antibody, clone 8E11, FITC conjugated

  • merck millipore,默克密理博,CBL418F,Anti-Endoglin Antibody, clone 8E11, FITC conjugated

    产品名称：Anti-Endoglin Antibody, clone 8E11, FITC conjugated
    产品型号：CBL418F
    Anti-Endoglin Antibody, clone 8E11, FITC conjugated detects level of Endoglin & has been published & validated for use in FC & IF.

    merck millipore,默克密理博,CBL418F,Anti-Endoglin Antibody, clone 8E11, FITC conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL418F,Anti-Endoglin Antibody, clone 8E11, FITC conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 CBL418F
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Endoglin Antibody, clone 8E11, FITC conjugated
    Alternate Names
    • ancillary TGF-beta Receptor
    • CD105
    产品信息
    格式 FITC
    演示 The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin.
    应用
    应用 Anti-Endoglin Antibody, clone 8E11, FITC conjugated detects level of Endoglin & has been published & validated for use in FC & IF.
    主要应用
    • Flow Cytometry
    应用说明 Study of monocyte differentiation into macrophages and endoglin up-regulation.

    Studies in cellular adhesion of circulating blood cells.

    Lysis of CD105+ cells in the presence of complement.

    Identification of CD105 positive cells on frozen tissue sections.

    Flow cytometry: use 10μL of conjugate per test

    We recommend that each laboratory determine an optimum working titre for use in its particular application.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 PMA-induced U-937 cells. U-937 is an human lymphoma cell line that expresses markers and properties of monocytes.
    克隆 8E11
    宿主 Mouse
    特异性 Endoglin is an endothelial homodimeric membrane antigen containing the tripeptide sequence RGD, which is a recognition motif for adhesion receptors of the integrin family. It has been proposed that endoglin is a TGF-beta receptor. Endoglin is a glycoprotein present on endothelial cells of capillaries, arterioles and venules in a variety of tissues and at low levels on acute lymphoblastic and myelocytic leukaemia cells.

    FUSION PARTNER: NS1 myeloma cell line.
    同种型 IgM
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000118.1
    Entrez基因汇总 Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • endoglin
    • ENG
    • ORW
    • CD105
    • HHT1
    • END
    • FLJ41744
    • ORW1
    UniProt编号
    • P17813
    UniProt汇总 FUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
    SIZE: 658 amino acids; 70578 Da
    SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
    DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL418F,Anti-Endoglin Antibody, clone 8E11, FITC conjugated

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