merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB10750,Anti-LIMK1 Antibody, clone 40/00-1B11-1-1

  • merck millipore,默克密理博,MAB10750,Anti-LIMK1 Antibody, clone 40/00-1B11-1-1

    产品名称：Anti-LIMK1 Antibody, clone 40/00-1B11-1-1
    产品型号：MAB10750
    This Anti-LIMK1 Antibody, clone 40/00-1B11-1-1 is validated for use in WB, IP, IC, IH for the detection of LIMK1.

    merck millipore,默克密理博,MAB10750,Anti-LIMK1 Antibody, clone 40/00-1B11-1-1

  • 产品介绍
  • merck millipore,默克密理博,MAB10750,Anti-LIMK1 Antibody, clone 40/00-1B11-1-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WB, ICCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB10750
    描述 Anti-LIMK1 Antibody, clone 40/00-1B11-1-1
    Alternate Names
    • LIM motif-containing protein kinase
    • LIM domain kinase 1
    背景信息 LIM Kinase 1 (LIMK1) is a protein kinase that plays an important role in cellular functions like cell motility and growth cone actin dynamics. LIMK1 contains one PDZ domain and two LIM domains which mediate protein to protein inteactions. It is widely expressed in the adult and fetal nervous system with the highest levels being found in the cerebral cortex. Mutations in LIMK1 have been associated with cardiovascular and musculo-skeletal abnormalities.
    产品信息
    格式 Purified
    控制
    • PC3 cell lysate
    演示 Purified in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 This Anti-LIMK1 Antibody, clone 40/00-1B11-1-1 is validated for use in WB, IP, IC, IH for the detection of LIMK1.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to a region of mouse LIMK1.
    表位 Unknown
    克隆 40/00-1B11-1-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 The antibody recognizes LIMK1.
    同种型 IgG2aκ
    品种反应性 MouseHuman
    Species Reactivity Note Human. Predicted to react with mouse based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_010717.2
    Entrez基因汇总 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
    基因符号
    • Limk1
    • Limk
    纯化方法 Protein G purfied
    UniProt编号
    • P53668
    UniProt汇总 FUNCTION: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton.

    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

    SUBUNIT STURCTURE: Self-associates. Binds ROCK1 By similarity. The LIM domain interacts with the cytoplasmic domain of NRG1. Interacts with NISCH and SSH1.

    SUBCELLULAR LOCATION: Cytoplasm.

    TISSUE SPECIFICITY: Highest expression in the nervous system, particularly in the spinal cord and the cranial nerve and dorsal root ganglia.

    PTM: Autophosphorylated By similarity.

    Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.

    INVOLVEMENT IN DISEASE: Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

    Contains 2 LIM zinc-binding domains.

    Contains 1 PDZ (DHR) domain.

    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in PC3 cell lysate.

    Western Blot Analysis: 0.5 µg/ml of this antibody detected LIMK1 on 10 µg of PC3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB10750,Anti-LIMK1 Antibody, clone 40/00-1B11-1-1

上一件merck millipore产品：merck millipore,默克密理博,AB6070,Anti-MT1-MMP Antibody, hemopexin domain
下一件merck millipore产品：merck millipore,默克密理博,201125,Binucleine 2 - CAS 220088-42-6 - Calbiochem


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