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  • merck millipore,默克密理博,ABS52,Anti-phospho-SMAD1 (Ser206) Antibody

  • merck millipore,默克密理博,ABS52,Anti-phospho-SMAD1 (Ser206) Antibody

    产品名称：Anti-phospho-SMAD1 (Ser206) Antibody
    产品型号：ABS52
    This Anti-phospho-SMAD1 (Ser206) Antibody is validated for use in Western Blotting for the detection of phospho-SMAD1 (Ser206).

    merck millipore,默克密理博,ABS52,Anti-phospho-SMAD1 (Ser206) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABS52,Anti-phospho-SMAD1 (Ser206) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABS52
    描述 Anti-phospho-SMAD1 (Ser206) Antibody
    Alternate Names
    • transforming growth factor-beta signaling protein 1
    • MAD, mothers against decapentaplegic homolog 1
    • MAD, mothers against decapentaplegic homolog 1 (Drosophila)
    • Mad-related protein 1
    • Mothers against DPP homolog 1
    • SMAD 1
    • SMAD family member 1
    • SMAD, mothers against DPP homolog 1
    • SMAD, mothers against DPP homolog 1 (Drosophila)
    • Sma- and Mad-related protein 1
    • TGF-beta signaling protein 1
    • transforming growth factor-beta-signaling protein 1
    背景信息 Smad proteins are regulators of transcription which transduce signals from TGFβ Receptors. Smad proteins homotrimerize, and when activated, two distinct homotrimers assemble into a heterosextamer. Smad proteins fall into three classes. The receptor-regulated Smad proteins, Smad 1, 2, 3, 5, and 9 couple to specific receptors and are phosphorylated by those receptors. Phosphorylated receptor-regulated Smad proteins then bind to a co-Smad, such as Smad4/DPC4, and the complex moves to the nucleus where it associates with FAST-1 to stimulate target gene transcription. A third class of Smad proteins is the inhibitory group of Smad 6, 7, 8. Smad proteins have Mad-homology domains 1 and 2 (MH1 and MH2). MH1 domains are involved in DNA binding, while MH2 domains function in homotrimerization, receptor interaction and phosphorylation. The phosphorylation of Smad proteins is the regulatory signal in their activation, and can be monitored by the use of phosphorylation state-specific antibodies.
    产品信息
    格式 Affinity Purified
    控制
    • Untreated and BMP2 treated HEK293 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-phospho-SMAD1 (Ser206) Antibody is validated for use in Western Blotting for the detection of phospho-SMAD1 (Ser206).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human SMAD1 phosphorylated at Ser206.
    表位 Phosphorylated Ser206
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes SMAD1 phosphorylated at Ser206.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rat, Bovine, and Porcine based on 100% sequence homology. Other homologies: Mouse (93% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005891
    基因符号
    • HMN5
    • BSP-1
    • BSP1
    • CMT2D
    • GARS
    纯化方法 Affinity purified
    UniProt编号
    • Q15797
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and BMP2 treated HEK293 cell lysates.

    Western Blot Analysis: 0.2 µg/mL of this antibody detected SMAD2 in 10 µg of untreated and BMP2 treated HEK293 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABS52,Anti-phospho-SMAD1 (Ser206) Antibody

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