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merck millipore,默克密理博,IHCR1005-6,Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1
产品名称：Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1
产品型号：IHCR1005-6
Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1 detects level of Tyrosine Hydroxylase & has been published & validated for use in IH(P).
merck millipore,默克密理博,IHCR1005-6,Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Zebrafish, Ch, H, M, Mk, R, Fg, Lz, Vo IH(P) M Purified Monoclonal Antibody 描述 产品目录编号 IHCR1005-6 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1 背景信息 Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. 产品信息 格式 Purified 演示 Liquid diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as preservative. 应用 应用 Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1 detects level of Tyrosine Hydroxylase & has been published & validated for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.
Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.
Incubation: 30 minutes with IHC Select® Detection Kits.
Tyrosine Hydroxylase has been prediluted for use as the primary antibody with Chemicon's IHC Select® Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used.生物信息 免疫原品种 Tyrosine Hydroxylase purified from PC12 cells. 表位 Recognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. 克隆 LNC1 宿主 Mouse 特异性 Tyrosine Hydroxylase. Recognizes a protein of approximately 59-63 kDa by Western blot. Does not react with the following on Western Blots: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, phenethanolamine-N-methyl transferase (PNMT). 同种型 IgG1κ 品种反应性 ZebrafishChickenHumanMouseMonkeyRatFrogLizardVole 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_199293.2
- NM_000360.3
- NM_199292.2
Entrez基因汇总 Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. 基因符号 - EC 1.14.16.2
- TH
- TYH
UniProt编号 - P07101
UniProt汇总 FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
COFACTOR: Fe(2+) ion.
SIZE: 528 amino acids; 58524 Da
TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C. Refer to vial for expiration dating. 包装信息 数量 6 mL
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