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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-945 品牌系列 Upstate
商名 - Upstate
描述 Anti-NKG2D Antibody, clone 3.1.1.1 产品信息 格式 Purified 应用 应用 Detect NKG2D using this Anti-NKG2D Antibody, clone 3.1.1.1 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 6His-tagged fusion protein corresponding to residues 85-216 of human NKG2D 克隆 clone 3.1.1.1 宿主 Mouse 特异性 NKG2D 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_007360
Entrez基因汇总 Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. 基因符号 - NKG2-D
- KLRK1
- KLR
- NKG2D
- CD314
- D12S2489E
纯化方法 Protein A purfied UniProt编号 - P26718
UniProt汇总 FUNCTION: SwissProt: P26718 # Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
SIZE: 216 amino acids; 25274 Da
SUBUNIT: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells.
SIMILARITY: SwissProt: P26718 ## Contains 1 C-type lectin domain.
MISCELLANEOUS: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.产品使用声明 质量保证 Routinely evaluated by immunoblot in RIPA lysates from human Natural Killer cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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