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品种反应性 主要应用 宿主 格式 抗体类型 Sh, M, R IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB9754 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Kisspeptin Antibody Alternate Names - kp10
产品信息 格式 Serum 演示 Rabbit serum.Liquid containing 50% glycerol, Ph 7.4, Phosphate buffer 0.01M. 应用 应用 Anti-Kisspeptin Antibody detects level of Kisspeptin & has been published & validated for use in IH, RIA. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry on 4% paraformaldehyde fixed tissue: 1:500-1:1,000 (PAP and ABC with NiDAB detection system).
RIA: 1:500-1:10,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Peptide from mouse kisspeptin 10. The sequence is common to all kisspeptin isoforms. 宿主 Rabbit 特异性 Kisspeptin 10 (kp10, metastin). No cross reactivity with GnRH, Galatin, SP, NPY, CRH, alphaMSH, SRIF or PrRP by RIA. 品种反应性 SheepMouseRat Species Reactivity Note The antibody showed a very low level of reactivity with human kp10. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002256.3
Entrez基因汇总 This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. 基因符号 - MGC39258
- KISS1
- metastin
- KiSS-1
- Kisspeptin-1
- kisspeptin
- ORFNames=PP5098
纯化方法 Serum UniProt编号 - Q15726
UniProt汇总 FUNCTION: SwissProt: Q15726 # Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
SIZE: 145 amino acids; 15332 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
PTM: Processed by MMP2 and MMP9.
SIMILARITY: SwissProt: Q15726 ## Belongs to the KISS1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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