• merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody
  • merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody

    产品名称:Anti-Caspase 1 Antibody
    产品型号:06-503-I
    Anti-Caspase 1 Antibody is a highly specific rabbit polyclonal antibody, that targets Caspase 1 & has been tested in western blotting & IHC (Paraffin).

    merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-503-I
    Replaces 06-503
    描述 Anti-Caspase 1 Antibody
    Alternate Names
    • p45
    • Caspase-1
    • CASP-1
    • Interleukin-1 beta convertase
    • IL-1BC
    • Interleukin-1 beta-converting enzyme
    • ICE
    • IL-1 beta-converting enzyme
    背景信息 Caspase-1, also known as IL-1 beta-converting enzyme (ICE), is an enzyme that cleaves the inflammatory cytokines IL-1 beta and IL-18, releasing the mature, active peptides. Caspase-1 is important for defense against pathogens and it also is involved in the induction of apoptosis. Thymocytes from caspase-1 deficient mice are resistant to Fas-mediated apoptosis, and caspase-1 is similar to the cell death gene CED-3 of C. elegans. Caspase-1 is a heterotetramer that consists of two anti-parallel heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The enzyme has a preferred cleavage site of Tyr-Val-Ala-Asp (YVAD). Caspase-1 is highly expressed in spleen and lung, and is absent from brain.
    产品信息
    格式 Affinity Purified
    控制
    • THP cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Caspase 1 Antibody is a highly specific rabbit polyclonal antibody, that targets Caspase 1 & has been tested in western blotting & IHC (Paraffin).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Caspase 1 in human spleen tissue. Additionally, a 1:4,000 dilution from a representative lot detected Caspase 1 in human colon tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the p20 subunit of human Caspase 1.
    表位 p20 subunit
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the p20 subunit of Caspase 1. This antibody may cross-react with Caspase 5 due to 92% sequence homology. Additionally, this antibody recognizes the P45 proenzyme (~45 kDa) and the p20 subunit (~20 kDa) of the reduced, human Caspase 1 isoforms.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Other homologies: Mouse, rat, canine, porcine and feline. (92% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001214
    基因符号
    • IL1BCE
    • CASP1
    • IL1BC
    纯化方法 Affinity purified
    UniProt编号
    • P29466
    产品使用声明
    质量保证 Evaluated by Western Blotting in THP-1 cell lysate.

    Western Blotting Analysis: 5 µg/mL of this antibody detected Caspase 1 in 10 µg THP-1 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody

上一件merck millipore产品:merck millipore,默克密理博,MAB5434,Anti-Oct-1 Antibody, clone YL15
下一件merck millipore产品:merck millipore,默克密理博,05-755,Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32



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