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merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody
产品名称:Anti-Caspase 1 Antibody
产品型号:06-503-I
Anti-Caspase 1 Antibody is a highly specific rabbit polyclonal antibody, that targets Caspase 1 & has been tested in western blotting & IHC (Paraffin).
merck millipore,默克密理博,06-503-I,Anti-Caspase 1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-503-I Replaces 06-503 描述 Anti-Caspase 1 Antibody Alternate Names - p45
- Caspase-1
- CASP-1
- Interleukin-1 beta convertase
- IL-1BC
- Interleukin-1 beta-converting enzyme
- ICE
- IL-1 beta-converting enzyme
背景信息 Caspase-1, also known as IL-1 beta-converting enzyme (ICE), is an enzyme that cleaves the inflammatory cytokines IL-1 beta and IL-18, releasing the mature, active peptides. Caspase-1 is important for defense against pathogens and it also is involved in the induction of apoptosis. Thymocytes from caspase-1 deficient mice are resistant to Fas-mediated apoptosis, and caspase-1 is similar to the cell death gene CED-3 of C. elegans. Caspase-1 is a heterotetramer that consists of two anti-parallel heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The enzyme has a preferred cleavage site of Tyr-Val-Ala-Asp (YVAD). Caspase-1 is highly expressed in spleen and lung, and is absent from brain. 产品信息 格式 Affinity Purified 控制 - THP cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Caspase 1 Antibody is a highly specific rabbit polyclonal antibody, that targets Caspase 1 & has been tested in western blotting & IHC (Paraffin). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Caspase 1 in human spleen tissue. Additionally, a 1:4,000 dilution from a representative lot detected Caspase 1 in human colon tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the p20 subunit of human Caspase 1. 表位 p20 subunit 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the p20 subunit of Caspase 1. This antibody may cross-react with Caspase 5 due to 92% sequence homology. Additionally, this antibody recognizes the P45 proenzyme (~45 kDa) and the p20 subunit (~20 kDa) of the reduced, human Caspase 1 isoforms. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Other homologies: Mouse, rat, canine, porcine and feline. (92% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001214
基因符号 - IL1BCE
- CASP1
- IL1BC
纯化方法 Affinity purified UniProt编号 - P29466
产品使用声明 质量保证 Evaluated by Western Blotting in THP-1 cell lysate.
Western Blotting Analysis: 5 µg/mL of this antibody detected Caspase 1 in 10 µg THP-1 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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