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merck millipore,默克密理博,05-755,Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32
产品名称：Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32
产品型号：05-755
This Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32 is validated for use in IP, WB, IC, IH for the detection of MEL-CAM (MUC18.
merck millipore,默克密理博,05-755,Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Human Only IHC, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-755 品牌系列 Upstate
商名 - Upstate
描述 Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32 概述 MEL-CAM is also known as MUC18, CD146, S-Endo-1, or A32 melanoma-associated antigen 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32 is validated for use in IP, WB, IC, IH for the detection of MEL-CAM (MUC18. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 human primary WM902B melanoma cells 克隆 A32 宿主 Mouse 特异性 MEL-CAM 同种型 IgG1κ 品种反应性 Human Only 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006500
基因符号 - CD146
- MCAM
- MUC18
- Gicerin
纯化方法 Protein G purfied UniProt编号 - P43121
UniProt汇总 FUNCTION: SwissProt: P43121 # Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
SIZE: 646 amino acids; 71607 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
SIMILARITY: SwissProt: P43121 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 Ig-like V-type (immunoglobulin-like) domains.产品使用声明 质量保证 routinely evaluated by immunoblot on SK-Mel-37 melanoma cell lysates 销售限制 Due to license agreement restrictions, this product cannot be purchased for resale. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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