merck millipore,默克密理博,662107,UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8

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Merck Millipore 默克密理愽

merck millipore,默克密理博,662107,UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem

经验配方	CAS号
C₁₁H₉NO₅S	343351-67-8

描述
概述	A cell-permeable nitrofuran compound that selectively inhibits the E2 Ubiquitin-conjugating enzyme Ubc13- (Cat. No. 438075), but not UbcH5c-, catalyzed K63-linked polyUb chain formation by preventing Ubc13-Ub thioester bond formation. Effectively inhibits Ubc13-Uev1A (UBE2V1) E2 complex-mediated NF-κB activation, Ubc13-Mms2 (UBEV2) E2 complex-mediated DNA DSB (double-strand break) repair activation, as well as Ubc13-dependent p53 nuclear export in cultures (1 to 2 µM). The combined NF-κB inhibition and p53 activation via Ubc13 inhibition is shown to be particularly effective against the proliferation of ABC (Activated B-cell-like) and GCB (Germinal center B-cell-like) DLBCL (Diffuse Large B-Cell Lymphoma) cell lines and primary DLBCL cultures via apoptosis induction (1 to 2 µM).
产品目录编号	662107
品牌系列	Calbiochem®
同义词	Ubc13 Inhibitor, NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor, 2-Nitro-5-tosylfuran

参考
参考	Pulvino, M., et al. 2012. Blood 1668.

生物信息
主靶	Ubc13
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,662107,UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem

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