merck millipore,默克密理愽
  • merck millipore,默克密理博,17-284,p300/CBP Immunoprecipitation HAT Assay Kit

  • merck millipore,默克密理博,17-284,p300/CBP Immunoprecipitation HAT Assay Kit

    产品名称：p300/CBP Immunoprecipitation HAT Assay Kit
    产品型号：17-284
    The p300/CBP Immunoprecipitation HAT Assay Kit contains nonradioactive components for assessing the histone acetyl transferase (HAT) activity ofimmunoprecipitated p300/CBP.

    merck millipore,默克密理博,17-284,p300/CBP Immunoprecipitation HAT Assay Kit

  • 产品介绍
  • merck millipore,默克密理博,17-284,p300/CBP Immunoprecipitation HAT Assay Kit

    重要规格表

    品种反应性 主要应用 检测方法
    R, H, MHATRadioactive
    描述
    产品目录编号 17-284
    品牌系列 Upstate
    商名
    • Upstate
    描述 p300/CBP Immunoprecipitation HAT Assay Kit
    Alternate Names
    • KAT3B
    • KAT3A
    产品信息
    部件
    • Histone H4 Peptide, biotin conjugate, residues 2-24 (Cat.# 12-372)
    • Anti-p300 CT, clone RW128 (Cat.# 05-257)
    • HAT Assay Buffer, 5X (Cat.# 20-148)
    • P81 Phosphocellulose Squares (Cat.# 20-134)
    检测方法 Radioactive
    应用
    应用 The p300/CBP Immunoprecipitation HAT Assay Kit contains nonradioactive components for assessing the histone acetyl transferase (HAT) activity of
    immunoprecipitated p300/CBP.
    主要应用
    • Histone Acetyltransferase Assay (HAT)
    生物信息
    宿主 Mouse
    品种反应性 RatHumanMouse
    Entrez基因编号
    • NM_004380.2
    • NM_001079846.1
    Entrez基因汇总 EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
    基因符号
    • RSTS
    • CREBBP
    • CBP
    • RTS
    UniProt编号
    • Q09472
    • Q92793
    UniProt汇总 FUNCTION: SwissProt: Q92793 # Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes.
    SIZE: 2442 amino acids; 265351 Da
    SUBUNIT: Found in a complex containing NCOA2; NCOA3; IKKA; IKKB and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with phosphorylated CREB1. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax and p30II. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Nucleus.
    DOMAIN:SwissProt: Q92793 The KIX domain mediates binding to HIV-1 Tat.
    PTM: Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.
    DISEASE: SwissProt: Q92793 # Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. & Defects in CREBBP are a cause of Rubinstein-Taybi syndrome (RSTS) [MIM:180849]. RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
    SIMILARITY: Contains 1 bromo domain. & Contains 1 KIX domain. & Contains 2 TAZ-type zinc fingers. & Contains 1 ZZ-type zinc finger.
    产品使用声明
    质量保证 Routinely evaluated by immunoprecipitating HeLa nuclear extract with either normal mouse IgG or anti- p300. The immune complexes were subjected to a HAT assay using Histone H4 Peptide, biotinylated
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 1 kit
    包装 Kit capacity: 40 assays

    merck millipore,默克密理博,17-284,p300/CBP Immunoprecipitation HAT Assay Kit

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