merck millipore,默克密理愽
  • merck millipore,默克密理博,07-018-I,Anti-phospho-p70 S6 Kinase (Thr389) Antibody

  • merck millipore,默克密理博,07-018-I,Anti-phospho-p70 S6 Kinase (Thr389) Antibody

    产品名称：Anti-phospho-p70 S6 Kinase (Thr389) Antibody
    产品型号：07-018-I
    Detect phospho-p70 S6 Kinase (Thr389) using this Anti-phospho-p70 S6 Kinase (Thr389) Antibody validated for use in Western Blotting, Peptide Inhibition Assay.

    merck millipore,默克密理博,07-018-I,Anti-phospho-p70 S6 Kinase (Thr389) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-018-I,Anti-phospho-p70 S6 Kinase (Thr389) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-018-I
    描述 Anti-phospho-p70 S6 Kinase (Thr389) Antibody
    Alternate Names
    • p70 S6KA
    • Ribosomal protein S6 kinase
    • S6K-beta-1
    • S6K1
    • p70S6K1
    • p70 S6K1
    • p70-S6K1
    背景信息 The p70 S6 kinase is a ubiquitous cytoplasmic protein that is activated in response to cytokines, and growth factors including the epidermal growth factor and fibroblast growth factor. It lies downstream of the mTOR/PI3K pathway and is phosphorylated on multiple residues: Thr389, Thr229, Thr421, Ser371, Ser404, Ser411, Ser418, and Ser424. Thr389, Ser371, and Ser404 are located in the linker domain; whereas Thr421, Ser411, Ser418, Ser424 are located in the autoinhibitory domain, and Thr229 is found in the catalytic domain. These sites may be phosphorylated in a hierarchical sequence leading to the activation of the p70 S6 kinase. The p70 S6 kinase phosphorylates the S6 protein on the 40S ribosomal protein (rpS6), and plays a role in multiple processes including regulation of mRNA molecules with 5’-terminal oligopyrimidine tracts, protein synthesis, cell growth, proliferation, and cell survival. The activity of this kinase may be important in diabetes, cancer, and aging.
    产品信息
    格式 Affinity Purified
    控制
    • MCF7 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect phospho-p70 S6 Kinase (Thr389) using this Anti-phospho-p70 S6 Kinase (Thr389) Antibody validated for use in Western Blotting, Peptide Inhibition Assay.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the AGC-kinase C-terminal of human Ribosomal protein S6 kinase beta-1
    phosphorylated at Thr389.
    表位 AGC-kinase C-terminal
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the AGC-kinase C-terminal of Ribosomal protein S6 kinase beta-1 phosphorylated at Thr389.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, Chicken, Zebra Fish, and Bovine based on 100% sequence homology. Other homologies: ribosomal protein S6 kinase beta-2 (91% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003152
    基因符号
    • STK14A
    • RPS6KB1
    纯化方法 Affinity purified
    UniProt编号
    • P23443
    产品使用声明
    质量保证 Evaluated by Western Blot (Peptide Inhibition) Analysis in MCF7 cell lysate and MCF7 cell lysate with non-phospho or phospho peptide.

    Western Blot (Peptide Inhibition) Analysis: 1.0 µg/mL of this antibody detected p70 S6 Kinase phosphorylated at Thr389 in 10 µg of MCF7 cell lysate and MCF7 cell lysate incubated with a non-phospho peptide.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-018-I,Anti-phospho-p70 S6 Kinase (Thr389) Antibody

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