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merck millipore,默克密理博,219474,Cathepsin G Substrate IV, Fluorogenic - Calbiochem
产品名称：Cathepsin G Substrate IV, Fluorogenic - Calbiochem
产品型号：219474
An internally quenched fluorogenic peptide substrate (Mca/Anb as fluorophore/quencher) that is preferentially cleaved by cathepsin G between Gnf and Ser with high efficiency and selectivity.
merck millipore,默克密理博,219474,Cathepsin G Substrate IV, Fluorogenic - Calbiochem
- 产品介绍
重要规格表
描述 概述 An internally quenched fluorogenic peptide substrate (Mca/Anb as fluorophore/quencher) that is preferentially cleaved by cathepsin G between Gnf and Ser with high efficiency and selectivity (kcat = 0.524 s-1; KM = 2.08 µM; kcat/KM = 252,000 M-1s-1) as well as sensitivity (≤70 pM Cath G; [subsrate] = 3.3 µM). Human neutrophil elastase and proteinase 3 are found to cleave the peptide between Val and Thr with a much slower kinetics (no detectable cleavage in 1 h) and lower efficiency (10% and 23% cleavage, respectively, after 24 h). Mca = 7-Methoxycoumarin-4-yl acetyl; Gnf = 4-Guanidine-L-phenylalanine; Anb = Amino nitrobenzoic acid. 产品目录编号 219474 品牌系列 Calbiochem®
同义词 Mca-FVT-Gnf-SW-Anb-NH₂ 参考 参考 Lesner, A., et al. 2008. Anal. Biochem. 375, 306. 产品信息 形式 Lyophilized solid 配方 Supplied as a trifluoroacetate salt Hill配方 C₆₁H₆₇N₁₃O₁₅ 化学配方 C₆₁H₆₇N₁₃O₁₅ Molar Mass 1222.3 吸湿 Hygroscopic
肽序列 Mca-Phe-Val-Thr-Gnf~Ser-Trp-Anb-NH₂ 生物信息 纯度 ≥97% by HPLC 理化信息 最大排放 400 nm 最大激励 325 nm 溶解度 DMSO 肽序列 Mca-Phe-Val-Thr-Gnf~Ser-Trp-Anb-NH₂ 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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