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品种反应性 主要应用 宿主 格式 抗体类型 Sh, B, Ch, H, M, R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB9742 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-14-3-3 σ Antibody 背景信息 Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.
The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.产品信息 格式 Serum 演示 Liquid. 应用 应用 Anti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:3000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide from the N-terminal area of sheep 14-3-3 sigma. 宿主 Rabbit 特异性 14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein. 品种反应性 SheepBovineChickenHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006142.3
基因符号 - Stratifin
- SFN
- YWHAS
- HME1
- stratifin
纯化方法 Serum UniProt编号 - P31947
UniProt汇总 FUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.
SIZE: 248 amino acids; 27774 Da
SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,14-584M,PAK4 Protein, active, 250 µg
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