merck millipore,默克密理愽
  • merck millipore,默克密理博,506181,p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

  • merck millipore,默克密理博,506181,p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

    产品名称：p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem
    产品型号：506181
    The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications More>>

    merck millipore,默克密理博,506181,p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506181,p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

    重要规格表

    经验配方
    C₁₅₀H₂₂₇N₅₇O₃₂S₂
    描述
    概述 The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
    产品目录编号 506181
    品牌系列 Calbiochem®
    同义词 TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
    参考
    参考 Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
    Schwarze, S.R., et al. 1999. Science 285, 1569.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₅₀H₂₂₇N₅₇O₃₂S₂
    化学配方 C₁₅₀H₂₂₇N₅₇O₃₂S₂
    Molar Mass 3404.9
    吸湿 Hygroscopic
    肽序列 H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
    disulfide bond (12-26)
    可逆 N
    生物信息
    主靶 Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    肽序列 H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
    disulfide bond (12-26)
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,506181,p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

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