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描述 产品目录编号 14-584M 品牌系列 Upstate
商名 - Upstate
描述 PAK4 Protein, active, 250 µg 概述 expressed by baculovirus in Sf21 cells 应用 应用 Active, N-terminal His6 & N-terminal GST-tagged, recombinant, human PAK4 amino acids 295-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 N-terminal His6 and N-terminal GST-tagged, recombinant, human PAK4 amino acids 295-end 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005884.3
- NM_001014833.1
- NM_001014831.2
- NM_001014832.1
- NM_001014834.2
- NM_001014835.1
Entrez基因汇总 PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. 基因符号 - KIAA1142
- PAK4
- PAK-4
蛋白靶 PAK4 纯化方法 Glutathione agarose affinity chromatography 靶子系列 STE UniProt编号 - O96013
UniProt汇总 FUNCTION: SwissProt: O96013 # Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments.
SIZE: 591 amino acids; 64072 Da
SUBUNIT: Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1.
TISSUE SPECIFICITY: Highest expression in prostate, testis and colon.
PTM: Autophosphorylated on serine residues when activated by CDC42/p21. & Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity).
SIMILARITY: SwissProt: O96013 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP (Catalog #13-104) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-584) and in bulk (cat# 14-584-K).
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