merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1792P,Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form

  • merck millipore,默克密理博,AB1792P,Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form

    产品名称：Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form
    产品型号：AB1792P
    Detect Dopamine D2 Receptor using this Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form validated for use in ELISA, IH, IP & WB.

    merck millipore,默克密理博,AB1792P,Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form

  • 产品介绍
  • merck millipore,默克密理博,AB1792P,Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, CaWB, ELISA, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1792P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid at 1.0 mg/mL in PBS, pH 7.4 with 0.1% BSA and 0.02% sodium merthiolate.
    应用
    应用 Detect Dopamine D2 Receptor using this Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form validated for use in ELISA, IH, IP & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunohistochemistry
    应用说明 Western blot: 1-10 μg/mL (Chemiluminescence technique) The predicted size of D2L form is approximately 50 kDa. However, additional bands at approximately 60 and 100 kDa, and others are typically seen in various tissues (Boundy, et al. 1993; Sakata, et al. 1992; Farooqui et al. 1991, 1992; Brock et al. 1992; Farooqui & Prasad 1992). Approximately 100-400 μg of membrane protein/lane should be loaded to visualize various bands.

    Immunohistochemistry: 1-20 μg/mL on paraformaldehyde fixed sections.

    Immunoprecipitation: 1-10 μg using 100-400 μg of protein (Boundy, et al. 1993).

    ELISA: 0.5-1.0 μg/mL (1 μg/mL immunogen peptide (AG211)/well)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 27 amino acid peptide sequence from the rat D2 long form within the cytoplasmic loop #3.
    表位 cytoplasmic domain, long form
    宿主 Rabbit
    特异性 Specific for Dopamine Receptor D2 long form. Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L) forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3 (Dal Toso et al. 1989; Grandy et al. 1989; Monsma et al. 1990; Giros et al. 1989). D2L receptor is a 446 aa, G-protein coupled and transmembrane receptor protein (Boundy et al. 1993) The 27 aa rat D2RL peptide used for immunization was found only in the D2 long form and there is no significant homology with other dopamine receptors (D1, D2 short, and D3-D5).

    SPECIES REACTIVITIES: The immunogen peptide shows sequence homology of 96% with human/bovine (26/27 aa), 62% with Xenopus (17/27 aa) D2L receptors. Antibodies generated to the rat sequence have been shown to recognize the canine D2R (Boundy et al. 1993). Antibody cross-reactivity with various species is not known.
    品种反应性 RatCanine
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_016574.2
    • NM_000795.2
    Entrez基因汇总 This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
    基因符号
    • D2R
    • DRD2
    • D2DR
    • D
    UniProt编号
    • P14416
    UniProt汇总 FUNCTION: SwissProt: P14416 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
    SIZE: 443 amino acids; 50619 Da
    SUBUNIT: Interacts with GPRASP1, neurabin-2 and CLIC6 (By similarity). Interacts with CADPS and CADPS2.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: P14416 # It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia. & Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia, alcohol- responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
    SIMILARITY: SwissProt: P14416 ## Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB1792P,Anti-Dopamine D2 Receptor Antibody, cytoplasmic domain, long form

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