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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9600 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neuropilin-1 Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide. 应用 应用 Anti-Neuropilin-1 Antibody is an antibody against Neuropilin-1 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:500 on transfected COS-7 cells. The antibody reacts with the ~130 kDa
protein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04%
Tween 20.生物信息 免疫原品种 Synthetic peptide from the N-terminal CUB domain of human neuropilin-1. 宿主 Rabbit 特异性 Neuropilin-1. The immunogen sequence has low homology with neuropilin-2. 品种反应性 Human Species Reactivity Note It is expected that the antibody will also react with rat and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003873.4
- NM_001024628.1
- NM_001024629.1
Entrez基因汇总 NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] 基因符号 - CD304
- NRP1
- neuropilin-1
- DKFZp781F1414
- VEGF165R
- NRP
- DKFZp686A03134
UniProt编号 - O14786
UniProt汇总 FUNCTION: SwissProt: O14786 # The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
SIZE: 923 amino acids; 103120 Da
SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
SIMILARITY: SwissProt: O14786 ## Belongs to the neuropilin family. & Contains 2 CUB domains. & Contains 2 F5/8 type C domains. & Contains 1 MAM domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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