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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1924 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Laminin α5 Antibody, clone 4C7 产品信息 格式 Ascites 控制 - Developing striated muscle tissue
演示 UnPurified mouse ascites containing no preservatives. 应用 应用 Anti-Laminin α5 Antibody, clone 4C7 is an antibody against Laminin α5 for use in ELISA, IH & IP. 主要应用 - Immunohistochemistry
- ELISA
应用说明 ELISA (50% maximal binding to human laminin): >1:11,000.
Immunofluorescence - tissue staining pattern is most consistent with that observed for laminin alpha5 in the mouse(Miner et al., 1997)
Affinity chromatography
Immunoprecipitation
Does not work for Western blotting
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified human laminin 克隆 4C7 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with the globular domain of the alpha5 chain of intact laminin and blocks the neurite stimulating activity of laminin. This antibody was originally thought to recognize laminin alpha 1 or A, but further characterization has confirmed its specificity for the laminin alpha 5 chain [see Tiger, C.F. (1997) J. Biol. Chem. 272: 28590]. 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005560.3
Entrez基因汇总 Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. 基因符号 - KIAA0533
- LAMA5
- KIAA1907
纯化方法 Unpurified UniProt编号 - O15230
UniProt汇总 FUNCTION: SwissProt: O15230 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 3695 amino acids; 399755 Da
SUBUNIT: Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3) which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
TISSUE SPECIFICITY: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
DOMAIN: SwissProt: O15230 Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
SIMILARITY: Contains 22 laminin EGF-like domains. & Contains 5 laminin G-like domains. & Contains 1 laminin IV type A domain. & Contains 1 laminin N-terminal domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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