merck millipore,默克密理博,474787,MG-132, ≥95% by HPLC - CAS 133407-82-6

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merck millipore,默克密理博,474787,MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
产品名称：MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
产品型号：474787
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

merck millipore,默克密理博,474787,MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem

产品介绍

merck millipore,默克密理博,474787,MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₆H₄₁N₃O₅	133407-82-6

描述
概述	Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available. Also available as a 20 mM solution in DMSO (Cat. No. 474788).
产品目录编号	474787
品牌系列	Calbiochem®
同义词	Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Proteasome Inhibitor XI

参考
参考	Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761.

参考

Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.

产品信息
CAS号	133407-82-6
形式	White powder
Hill配方	C₂₆H₄₁N₃O₅
化学配方	C₂₆H₄₁N₃O₅
Molar Mass	475.6
结构配方图像

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.