- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
经验配方 CAS号 C₃₀H₂₈N₆O₆S₄ 28097-03-2 描述 概述 A naturally occurring cell-permeable Chaetomium fungal epi-dithio-diketopiperazine that potently inhibits the H3K9 histone methyltransferase activity of Drosophila melanogaster SU(VAR)3-9 and its human homologue SUV39H1 (IC50 = 600 and 800 nM, respectively) in a SAM-competitive manner, while exhibiting much reduced potency against murine G9a or Neurospora crassa DIM5 H3K9 HMT (IC50 = 2.5 and 3 µM, respectively) and no activity against the H3K27 HMTase activity of Drosophila E(z), the H3K4 activity of bacterial SET7/9, or the H4K20 activity of bacterial PRSET7. Although the reduction of intramolecular disulfide bonds of Chaetocin does not affect its HMTase inhibitory activity in cell-free enzymatic assays, the integrity of the disulfide bonds is shown to be essential for its cellular uptake. Myeloma cell lines as well as myeloma cells isolated from patients are shown to be especially susceptible to death upon H2O2 or Chaetocin treatment due to their heightened sensitivity to cellular oxidative stress induced by these agents. 产品目录编号 382191 品牌系列 Calbiochem®
同义词 HMT Inhibitor II, Histone Lysine Methyltransferase Inhibitor II, EHMT2/G9a Inhibitor II 参考 参考 Isham, C.R., et al. 2007. Blood 109, 2579.
Greiner, D., et al. 2005. Nat. Chem. Biol. 1, 143.产品信息 CAS号 28097-03-2 形式 White solid Hill配方 C₃₀H₂₈N₆O₆S₄ 化学配方 C₃₀H₂₈N₆O₆S₄ Molar Mass 696.9 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or CHCl₃ 安全信息 R相 R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.S相 S: 22-26-36-45
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
相关产品
merck millipore,默克密理博,ABF287,Anti-ABIN3 Antibody
merck millipore,默克密理博,07-868,Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody
merck millipore,默克密理博,444255,MMP Inhibitor Set I - CAS 161314-17-6 - Calbiochem
merck millipore,默克密理博,MABN654,Anti-SCN4B Antibody, clone N168/6
merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem
merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
merck millipore,默克密理博,MABC689,Anti-NUP96 Antibody, clone EPR6678, rabbit monoclonal
merck millipore,默克密理博,108371,酪氨酸
merck millipore,默克密理博,AB9600,Anti-Neuropilin-1 Antibody
merck millipore,默克密理博,474787,MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem