merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis

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merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem
产品名称：Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem
产品型号：516852
The pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells.

merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem

产品介绍

merck millipore,默克密理博,516852,Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem

描述
概述	The pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells. Reported to elicit direct cellular responses by binding to several cell surface receptors with oligosaccharide side chains. Also elicits a variety of physiological responses, such as mitogenesis in human T cells, enhancement of aggregation of human platelets, elevation of cytosolic Ca²⁺ levels, and neutralization of antibody response in mice. Reported to deactivate CCR5 and inhibit the entry of R5 HIV-1 in activated T lymphocytes. Also blocks post-entry step of HIV-1 replication.
产品目录编号	516852
品牌系列	Calbiochem®

参考
参考	Alfano, M., et al. 2001. J. Immunol. 166, 1863. Alfano, M., et al. 2000. J. Virol. 74, 8767. Hazes, B., et al. 1996. J. Mol. Biol. 258, 661. Wong, W.S., and Rosoff, P.M. 1996. Can. J. Physiol. Pharmacol. 74, 559. Banga, S., et al. 1987. J. Biol. Chem. 262, 14871. Burns, D.L., et al. 1987. Infect. Immun. 55, 24. Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198. Sato, Y., et al. 1983. Infect. Immun. 41, 313. Tamura, M., et al. 1982. Biochemistry 21, 5516.

参考

Alfano, M., et al. 2001. J. Immunol. 166, 1863.
Alfano, M., et al. 2000. J. Virol. 74, 8767.
Hazes, B., et al. 1996. J. Mol. Biol. 258, 661.
Wong, W.S., and Rosoff, P.M. 1996. Can. J. Physiol. Pharmacol. 74, 559.
Banga, S., et al. 1987. J. Biol. Chem. 262, 14871.
Burns, D.L., et al. 1987. Infect. Immun. 55, 24.
Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
Sato, Y., et al. 1983. Infect. Immun. 41, 313.
Tamura, M., et al. 1982. Biochemistry 21, 5516.

产品信息
具有ATP竞争性	N
形式	Lyophilized
可逆	N

生物信息
主靶	Cell surface receptors with oligosaccharide side chains
纯度	Four distinct bands by SDS-PAGE

理化信息
细胞可渗透	N
污染物	≤1% holotoxin by CHO cell assay
溶解度	H₂O or Aqueous Buffers

安全信息
R相	R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
S相	S: 45-36/37/39 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing, gloves and eye/face protection.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.