merck millipore,默克密理愽
  • merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

  • merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

    产品名称：cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
    产品型号：344036
    The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>

    merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₂N₄O₃870483-87-7
    描述
    概述 A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
    产品目录编号 344036
    品牌系列 Calbiochem®
    同义词 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
    参考
    参考 Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
    产品信息
    CAS号 870483-87-7
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₂₀H₂₂N₄O₃
    化学配方 C₂₀H₂₂N₄O₃
    Molar Mass 366.4
    可逆 N
    结构配方图像
    生物信息
    主靶 CFMS
    主靶IC50 30 nM against cFMS kinase activity
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,344036,cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

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