- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R IHC, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB757P Replaces AB757 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Collagen Type III Antibody 概述 Collagen Type III extracted and purified from rat skin. Antibody shows less than 0.1% reactivity with rat Collagen Type I and rat Elastin with less than 10.0% reactivity with rat Collagen Type V. 产品信息 格式 Purified 演示 Affinity purified immunoglobulin. Liquid, containing 0.01M phosphate, 0.09M NaCl, pH 7.2. No preservatives. 应用 应用 Detect Collagen Type III using this Anti-Collagen Type III Antibody validated for use in ELISA, RIA, IH. 主要应用 - Immunohistochemistry
- ELISA
不建议的应用 - Western Blotting
应用说明 Immunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen rat skin and liver tissues.
Radioimmunoassay
ELISA: 1:1000
Not recommended for paraffin tissue sections or Western blots.
Optimal working dilutions must be determined by the end user.生物信息 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Rat Type III 100%
Rat Type I < 0.1%
Rat Type V 9%
Mouse Type III 9%
Human Type I < 0.1%
Rat Elastin < 0.1%品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000090.3
Entrez基因汇总 This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish] 基因符号 - FLJ34534
- COL3A1
- EDS4A
UniProt编号 - P02461
UniProt汇总 FUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.
SIZE: 1466 amino acids; 138564 Da
SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.
SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,05-170,Anti-IL-2 Rα Antibody, clone 7G7/B6
下一件merck millipore产品：merck millipore,默克密理博,S7250,OxyELISA™ Oxidized Protein Quantitation Kit
相关产品
merck millipore,默克密理博,14-629,JAK3 Protein, active, 10 µg
merck millipore,默克密理博,EZHS100B-33K,Human S100B ELISA, EZHS100B-33K
merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody
merck millipore,默克密理博,HTS005M,ChemiSCREEN™ CCR1 Membrane Preparation
merck millipore,默克密理博,05-170,Anti-IL-2 Rα Antibody, clone 7G7/B6
merck millipore,默克密理博,S7250,OxyELISA™ Oxidized Protein Quantitation Kit
merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892
merck millipore,默克密理博,208920,Calmodulin Kinase IINtide - Calbiochem
merck millipore,默克密理博,69522,T7•Tag Monoclonal Antibody
merck millipore,默克密理博,407617,Interleukin-1β, Mouse, Recombinant, E. coli