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  • merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody

  • merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody

    产品名称：Anti-Girdin, coiled-coil region Antibody
    产品型号：ABT80
    This Anti-Girdin, coiled-coil region Antibody is validated for use in ICC, Western Blotting, Immunoprecipitation for the detection of Girdin, coiled-coil region.

    merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, HWB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABT80
    描述 Anti-Girdin, coiled-coil region Antibody
    背景信息 Girdin (Ccdc88a; APE, GIV, or HkRP1) is a ubiquitous protein belonging to the CCDC88 family. Girdin is an actin-binding protein which interacts with actin via its C-terminal domain, and may play a crucial role in cell motility and cytoskeleton remodeling. These effects may be regulated by a reciprocal relationship between Girdin and Akt. Akt phosphorylates Girdin, and Girdin binds to Akt and enhances phosphorylation of Akt, thereby promoting phosphorylation of Akt’s downstream targets such as GSK-3β and FOXO1A. Girdin/Akt signaling may play an important role in cancer by facilitating the proliferation of cancer cells.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa cells
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Girdin, coiled-coil region Antibody is validated for use in ICC, Western Blotting, Immunoprecipitation for the detection of Girdin, coiled-coil region.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: A 1:1000 dilution from a representative lot detected Girdin in Cos-7 cells (Prof. P. Ghosh, Department of Medicine, Division of Gastroenterology and Hepatology, UCSD School of Medicine and Veterans Affairs Medical Center).

    Western Blot Analysis: A representative lot detected Girdin in Cos-7 cell lysate. Uncharacterized bands may be observed in some cell lysates.

    Immunoprecipitation Analysis: A representative lot immunoprecipitated Girdin in HeLa cell lysates (Prof. P. Ghosh, Department of Medicine, Division of Gastroenterology and Hepatology, UCSD School of Medicine and Veterans Affairs Medical Center). Uncharacterized bands may be observed in some cell lysates.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to the coiled coil domain of rat Girdin.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 MonkeyHuman
    Species Reactivity Note Demonstrated to react with Human and Monkey. Predicted to react with Rat. Other Homologies: Mouse (97% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • XP_223709
    纯化方法 Affinity purified
    产品使用声明
    质量保证 Immunocytochemistry Analysis: A 1:1000 dilution of this antibody detected Girdin in HeLa cells (Prof. A. Ghosh, Division of Biology, UCSD).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABT80,Anti-Girdin, coiled-coil region Antibody

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