merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892

  • merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892

    产品名称：Anti-GABA B Receptor R2 Antibody, phosphoSer 892
    产品型号：AB5843
    Detect GABA B Receptor R2 using this Anti-GABA B Receptor R2 Antibody, phosphoSer 892 validated for use in IC, IH & WB.

    merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892

  • 产品介绍
  • merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5843
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-GABA B Receptor R2 Antibody, phosphoSer 892
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA
    with 50% glycerol.
    应用
    应用 Detect GABA B Receptor R2 using this Anti-GABA B Receptor R2 Antibody, phosphoSer 892 validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western blot: 1:1,000

    Immunohistochemistry: 1:1,000

    Immunocytochemistry: 1:1,000-1:2,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids surrounding the phosphoSer892 of rat GABA B receptor R2 subunit.
    表位 phosphoSer 892
    宿主 Rabbit
    特异性 GABA B Receptor R2, phosphoSer892. The antibody recognizes a protein of 110 kDa corresponding to GABA B Receptor R2, phosphoSer892.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005458.5
    Entrez基因汇总 B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]
    基因符号
    • GABABR2
    • GABBR2
    • HRIHFB2099
    • OTTHUMP00000063797
    • GPRC3B
    • GPR51
    • HG20
    • Gb2
    • FLJ36928
    • GABA-B-R2
    修改
    • Phosphorylation
    UniProt编号
    • O75899
    UniProt汇总 FUNCTION: SwissProt: O75899 # Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
    SIZE: 941 amino acids; 105821 Da
    SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
    TISSUE SPECIFICITY: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
    DOMAIN: SwissProt: O75899 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
    SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5843,Anti-GABA B Receptor R2 Antibody, phosphoSer 892

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