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品种反应性 主要应用 宿主 格式 抗体类型 R IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB5986 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Tyrosine Hydroxylase Antibody Alternate Names - Tyrosine Monooxygenase
- TH
产品信息 格式 Serum 控制 - POSITIVE CONTROL: brain (sympathetic nerve terminals) and adrenal glands.
演示 Rabbit serum. Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 This Anti-Tyrosine Hydroxylase Antibody is validated for use in IH for the detection of Tyrosine Hydroxylase. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry: 1:2,000-1:4,000.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 32-47 of rat Tyrosine Hydroxylase. 宿主 Rabbit 特异性 Tyrosine Hydroxylase. Immunohistochemical distribution throughout the brain shows that staining is restricted to those neurons known to contain the enzyme. The antibody has proven useful in staining catecholaminergic neurons. AB5986 stains these neurons intensely, including dendritic processes and fine nerve terminals. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_199293.2
- NM_000360.3
- NM_199292.2
Entrez基因汇总 Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. 基因符号 - EC 1.14.16.2
- TH
- TYH
UniProt编号 - P07101
UniProt汇总 FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
COFACTOR: Fe(2+) ion.
SIZE: 528 amino acids; 58524 Da
TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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