merck millipore,默克密理愽
  • merck millipore,默克密理博,401482,IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

  • merck millipore,默克密理博,401482,IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

    产品名称：IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem
    产品型号：401482
    The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,401482,IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401482,IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₈ClF₆NO₂978-62-1
    描述
    概述 A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 < 1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.
    产品目录编号 401482
    品牌系列 Calbiochem®
    同义词 N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
    参考
    参考 Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
    Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
    Tanaka, A., et al. 2004. Blood 105, 2324.
    产品信息
    CAS号 978-62-1
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₅H₈ClF₆NO₂
    化学配方 C₁₅H₈ClF₆NO₂
    Molar Mass 383.7
    可逆 N
    结构配方图像
    生物信息
    主靶 IKK-2
    主靶IC50 ~ 250 nM blocking IκBα phosphorylation
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401482,IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

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